Low TMB level could be the reason for the poor efficacy of ICBs in patients having EGFR mutation. And mutational
frequencies of KRAS and BRCA2 were lower in EGFR-mutant patients. Furthermore, ALK, CDKN2A, MAP2K1, IDH2
and PTEN might involve in the formation of immune phenotypes.
Onco Targets Ther. 2021 May 4;14:2953-2965.
Low prevalence of p16 and HPV associated OPSCC and non-OPSCC were confirmed in Thai patients. High
discordance and low positive predictive rates of p16 were observed in HPV-associated OPSCC. p16 was a significant
prognostic factor for OS for patients with OPSCC or non-OPSCC. Therefore, HPV testing should be performed to
assess the association of HPV with HNSCC regardless of p16 expression.
BMC Cancer. 2021 May 6;21(1):504.
Front Oncol. 2021 May 7;11:614052.
This protocol is applicable to circulating tumor cells analysis of peripheral blood and expands the possibility of
utilizing molecular profiling of cancers.
Cancer Sci. 2021 May;112(5):2006-2019.
We conclude that pulmonary resection for advanced NSCLC after targeted therapy is feasible, and the surgical
specimens could be used for planning further targeted therapy.
Cancers 2021, 13(11), 2549
This study illustrated the mutation patterns of HRR genes in Chinese population with localized and locally advanced
prostate cancer. These results provide further evidence that HRR gene mutations were more prevalent in patients
with higher Gleason grade, or with very-high-risk level. Patients with these clinicopathologic characteristics may
need more precise stratification through molecular detection.
Pathol Res Pract. 2021 May 29;224:153507.